Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0235 | 0.5737 | 0.5705 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.3691 | 0.3643 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0098 | 0.1229 | 0.2142 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0235 | 0.5737 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0123 | 0.2073 | 0.0954 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0098 | 0.1229 | 0.2142 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0235 | 0.5737 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0235 | 0.5737 | 0.3243 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0221 | 0.5279 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0235 | 0.5737 | 0.3243 |
Trypanosoma brucei | GMP reductase | 0.0235 | 0.5737 | 0.3243 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0235 | 0.5737 | 0.3243 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0235 | 0.5737 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0221 | 0.5279 | 0.8869 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0235 | 0.5737 | 0.5705 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0235 | 0.5737 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.4332 | 0.653 |
Trypanosoma cruzi | GMP reductase | 0.0235 | 0.5737 | 0.5705 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0235 | 0.5737 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0235 | 0.5737 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 1 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0235 | 0.5737 | 0.5 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0221 | 0.5279 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0235 | 0.5737 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0235 | 0.5737 | 0.5705 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Brugia malayi | GMP reductase | 0.0098 | 0.1229 | 0.2142 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0235 | 0.5737 | 0.5705 |
Toxoplasma gondii | IMP dehydrogenas | 0.0235 | 0.5737 | 0.5 |
Onchocerca volvulus | Putative GMP reductase | 0.0098 | 0.1229 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.4332 | 0.6164 |
Loa Loa (eye worm) | GMP reductase | 0.0098 | 0.1229 | 0.2142 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0235 | 0.5737 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.