Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0032 | 0.0101 | 0.0116 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0086 | 0.0956 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0086 | 0.0956 | 0.1105 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0159 | 0.2107 | 0.5156 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.033 | 0.0382 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.033 | 0.0382 |
Giardia lamblia | Kinesin-5 | 0.0086 | 0.0956 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0086 | 0.0956 | 0.2198 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0032 | 0.0101 | 0.0116 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0159 | 0.2107 | 0.2027 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0046 | 0.033 | 0.059 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0032 | 0.0101 | 0.0116 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.0101 | 0.0116 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0149 | 0.1942 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0577 | 0.865 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0159 | 0.2107 | 0.2027 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0174 | 0.2337 | 0.2702 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.3992 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0086 | 0.0956 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0046 | 0.033 | 0.0232 |
Entamoeba histolytica | kinesin, putative | 0.0086 | 0.0956 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0159 | 0.2107 | 0.5156 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1777 | 0.4307 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0046 | 0.033 | 0.0232 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0149 | 0.1942 | 1 |
Plasmodium vivax | kinesin-5 | 0.0086 | 0.0956 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0174 | 0.2337 | 0.2702 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.0101 | 0.0116 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0046 | 0.033 | 0.0232 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.3992 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0086 | 0.0956 | 0.2198 |
Echinococcus granulosus | voltage gated potassium channel | 0.0046 | 0.033 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.033 | 0.059 |
Echinococcus multilocularis | kinesin family 1 | 0.0663 | 1 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.0101 | 0.0116 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.