Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0037 | 0.0169 | 1 |
Leishmania major | choline kinase | 0.0037 | 0.0169 | 1 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0037 | 0.0169 | 0.0382 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0037 | 0.0169 | 0.0169 |
Echinococcus multilocularis | ethanolamine kinase 2 | 0.0037 | 0.0169 | 0.0169 |
Trypanosoma brucei | choline kinase | 0.0037 | 0.0169 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.0169 | 0.5 | |
Plasmodium vivax | choline kinase, putative | 0.0382 | 0.4425 | 1 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0037 | 0.0169 | 0.0382 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0037 | 0.0169 | 0.0169 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | choline/ethanolamine kinase, putative | 0.0037 | 0.0169 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0382 | 0.4425 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0382 | 0.4425 | 0.4425 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0382 | 0.4425 | 0.4425 |
Loa Loa (eye worm) | choline Kinase A | 0.0037 | 0.0169 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0169 | 0.0382 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0382 | 0.4425 | 1 |
Trypanosoma brucei | choline/ethanolamine kinase | 0.0037 | 0.0169 | 1 |
Schistosoma mansoni | choline kinase | 0.0037 | 0.0169 | 0.0169 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0382 | 0.4425 | 1 |
Giardia lamblia | Ethanolamine kinase, putative | 0.0037 | 0.0169 | 1 |
Trypanosoma cruzi | choline kinase | 0.0037 | 0.0169 | 1 |
Onchocerca volvulus | Putative choline\/ethanolamine kinase | 0.0037 | 0.0169 | 0.5 |
Echinococcus granulosus | ethanolamine kinase 2 | 0.0037 | 0.0169 | 0.0169 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Plasmodium falciparum | choline kinase | 0.0382 | 0.4425 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | choline ethanolamine kinase, putative | 0.0037 | 0.0169 | 1 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0037 | 0.0169 | 1 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0037 | 0.0169 | 0.0382 |
Leishmania major | choline/ethanolamine kinase, putative | 0.0037 | 0.0169 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.