Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0166 | 0.6551 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.9302 | 0.7976 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.9302 | 0.7976 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0166 | 0.6551 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.9302 | 0.7976 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0166 | 0.6551 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0166 | 0.6551 | 1 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0166 | 0.6551 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0166 | 0.6551 | 0.5 |
Onchocerca volvulus | 0.0114 | 0.1956 | 0.5 | |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0166 | 0.6551 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.6876 | 0.094 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0166 | 0.6551 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.9302 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0166 | 0.6551 | 0.5 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0166 | 0.6551 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.6876 | 0.094 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.9302 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1836 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.