Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.0394 | 0.3578 | 0.5567 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0593 | 0.6427 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0185 | 0.0581 | 0.0903 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0185 | 0.0581 | 0.0903 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0593 | 0.6427 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0185 | 0.0581 | 0.0903 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0593 | 0.6427 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0185 | 0.0581 | 0.0903 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0394 | 0.3578 | 0.5567 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0593 | 0.6427 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0208 | 0.0906 | 0.141 |
Echinococcus granulosus | carbonic anhydrase | 0.0185 | 0.0581 | 0.0903 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0208 | 0.0906 | 0.141 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0185 | 0.0581 | 0.0903 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0394 | 0.3578 | 0.3578 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0593 | 0.6427 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0593 | 0.6427 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0394 | 0.3578 | 0.5567 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0185 | 0.0581 | 0.0903 |
Echinococcus granulosus | carbonic anhydrase | 0.0185 | 0.0581 | 0.0903 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 0.6427 | 0.6427 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0394 | 0.3578 | 0.3578 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0593 | 0.6427 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0185 | 0.0581 | 0.0903 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0593 | 0.6427 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0593 | 0.6427 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0185 | 0.0581 | 0.0903 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0394 | 0.3578 | 0.5567 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0581 | 0.0581 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0593 | 0.6427 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0593 | 0.6427 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0593 | 0.6427 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0185 | 0.0581 | 0.0903 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0593 | 0.6427 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0593 | 0.6427 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0394 | 0.3578 | 0.5567 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0191 | 0.0656 | 0.0656 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0593 | 0.6427 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0295 | 0.0295 |
Mycobacterium ulcerans | hypothetical protein | 0.0145 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0581 | 0.0581 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0593 | 0.6427 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0394 | 0.3578 | 0.5567 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0593 | 0.6427 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0185 | 0.0581 | 0.0903 |
Echinococcus multilocularis | carbonic anhydrase | 0.0185 | 0.0581 | 0.0903 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0593 | 0.6427 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0191 | 0.0656 | 0.102 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0593 | 0.6427 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0185 | 0.0581 | 0.0903 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0191 | 0.0656 | 0.102 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0185 | 0.0581 | 0.0581 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0593 | 0.6427 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.0581 | 0.0903 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0191 | 0.0656 | 0.102 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0593 | 0.6427 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0185 | 0.0581 | 0.0903 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0593 | 0.6427 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0593 | 0.6427 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.