Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) | Diphosphomevalonate decarboxylase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Cuticle collagen 6 homolog | Diphosphomevalonate decarboxylase | 317 aa | 317 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.3418 | 0.3928 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1899 | 0.2155 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1899 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.0231 | 0.9992 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0088 | 0.2958 | 1 |
Schistosoma mansoni | diphosphomevalonate decarboxylase | 0.0057 | 0.1416 | 0.7385 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0137 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0873 | 0.0958 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.8618 | 1 |
Loa Loa (eye worm) | diphosphomevalonate decarboxylase | 0.0046 | 0.0873 | 0.0958 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0053 | 0.0373 |
Echinococcus granulosus | diphosphomevalonate decarboxylase | 0.0057 | 0.1416 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0137 | 0.0456 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0088 | 0.2958 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0088 | 0.2958 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0231 | 0.9992 | 0.5 |
Giardia lamblia | Diphosphomevalonate decarboxylase | 0.0057 | 0.1416 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0137 | 0.0098 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0137 | 0.0967 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0088 | 0.2958 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0137 | 0.0098 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0137 | 0.0456 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0088 | 0.2958 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.8618 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0137 | 0.0967 |
Toxoplasma gondii | hypothetical protein | 0.0231 | 0.9992 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0137 | 0.0617 |
Onchocerca volvulus | 0.0057 | 0.1416 | 0.1371 | |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0088 | 0.2958 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0088 | 0.2958 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0137 | 0.0456 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0137 | 0.0456 |
Chlamydia trachomatis | peptide deformylase | 0.0231 | 0.9992 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0137 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1899 | 0.2155 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0137 | 0.0617 |
Brugia malayi | diphosphomevalonate decarboxylase family protein | 0.0057 | 0.1416 | 0.1592 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0137 | 0.0617 |
Plasmodium falciparum | peptide deformylase | 0.0231 | 0.9992 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0231 | 0.9992 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0231 | 0.9992 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.0231 | 0.9992 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0137 | 0.0967 |
Echinococcus multilocularis | diphosphomevalonate decarboxylase | 0.0057 | 0.1416 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.3418 | 0.3928 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.3418 | 0.3928 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.3418 | 0.3928 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0231 | 0.9992 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 12.4 um | PUBCHEM_BIOASSAY: Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC - Secondary Assay. (Class of assay: confirmatory) [Related pubchem assays: 549, 556, 550, 557, 555, 1000, 539 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.