Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Glycogen phosphorylase | 0.3702 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.3702 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.3702 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.3702 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.3702 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.3702 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.3702 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.3702 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.3702 | 1 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.1601 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.1601 | 0 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.3702 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.3702 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.3702 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.3702 | 1 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.3702 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.3702 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.3702 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 30.1313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.