Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.037 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.037 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.037 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.037 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.037 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.037 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.037 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.037 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.037 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.037 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.037 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.037 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.037 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.037 | 0.5 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.037 | 0.5 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.037 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (binding) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.