Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0056 | 0.0164 | 0.5 |
Mycobacterium ulcerans | DNA polymerase I | 0.0056 | 0.0164 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.4281 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0618 | 0.2668 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.1644 | 0.7245 | 0.5 |
Chlamydia trachomatis | DNA polymerase I | 0.0056 | 0.0164 | 0.5 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0056 | 0.0164 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0618 | 0.2668 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0618 | 0.2668 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0618 | 0.2668 | 1 |
Treponema pallidum | DNA polymerase I (polA) | 0.0056 | 0.0164 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0618 | 0.2668 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0618 | 0.2668 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0618 | 0.2668 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0618 | 0.2668 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0056 | 0.0164 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3535 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (binding) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.