Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | CDC72 | 0.0175 | 0.3686 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0276 | 0.9881 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0131 | 0.099 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0131 | 0.099 | 0.5 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0175 | 0.3686 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0276 | 0.9881 | 0.5 |
Onchocerca volvulus | 0.0131 | 0.099 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0131 | 0.099 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0175 | 0.3686 | 0.373 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0175 | 0.3686 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0276 | 0.9881 | 1 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0175 | 0.3686 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.0175 | 0.3686 | 0.5 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0175 | 0.3686 | 1 |
Onchocerca volvulus | 0.0131 | 0.099 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0131 | 0.099 | 0.5 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0175 | 0.3686 | 0.3032 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0175 | 0.3686 | 0.5 |
Onchocerca volvulus | 0.0131 | 0.099 | 0.5 | |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0175 | 0.3686 | 0.5 |
Leishmania major | N-myristoyl transferase, putative | 0.0175 | 0.3686 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0131 | 0.099 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0175 | 0.3686 | 0.5 |
Brugia malayi | N-myristoyltransferase 2 | 0.0175 | 0.3686 | 0.3032 |
Schistosoma mansoni | glutaminase | 0.0276 | 0.9881 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0276 | 0.9881 | 1 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0175 | 0.3686 | 0.5 |
Schistosoma mansoni | N-myristoyltransferase | 0.0175 | 0.3686 | 0.3032 |
Trichomonas vaginalis | glutaminase, putative | 0.0276 | 0.9881 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0131 | 0.099 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.7783 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.