Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0749 | 0.2055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3431 | 1 | 1 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0749 | 0.2055 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Trypanosoma cruzi | putative prolyl carboxypeptidase, putative | 0.0749 | 0.2055 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.3431 | 1 | 1 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0749 | 0.2055 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0015 | 0.0015 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0749 | 0.2055 | 0.2055 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.3431 | 1 | 1 |
Giardia lamblia | Thymus-specific serine protease precursor | 0.0749 | 0.2055 | 0.5 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0749 | 0.2055 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0749 | 0.2055 | 0.2055 |
Giardia lamblia | Serine peptidase, putative | 0.0749 | 0.2055 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Onchocerca volvulus | 0.0749 | 0.2055 | 0.5 | |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Toxoplasma gondii | serine carboxypeptidase s28 protein | 0.0749 | 0.2055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0015 | 0.0015 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.3431 | 1 | 1 |
Trichomonas vaginalis | lysosomal pro-X carboxypeptidase, putative | 0.0749 | 0.2055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3431 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3431 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0749 | 0.2055 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0749 | 0.2055 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0749 | 0.2055 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0749 | 0.2055 | 0.5 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0749 | 0.2055 | 0.2055 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0015 | 0.0015 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0749 | 0.2055 | 0.2055 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0749 | 0.2055 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0749 | 0.2055 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0749 | 0.2055 | 0.2055 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0015 | 0.0015 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0749 | 0.2055 | 0.2055 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.