Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0162 | 0.1801 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0.0096 | 0.0139 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0308 | 0.4008 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0155 | 0.1687 | 0.1535 |
Mycobacterium ulcerans | hypothetical protein | 0.0162 | 0.1801 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0377 | 0.5046 | 0.4955 |
Echinococcus multilocularis | snurportin 1 | 0.0343 | 0.4537 | 0.4437 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0151 | 0.1621 | 0.1594 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0347 | 0.4589 | 1 |
Echinococcus multilocularis | geminin | 0.0377 | 0.5046 | 0.4955 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0053 | 0.0143 | 0.0358 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0155 | 0.1687 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0146 | 0.1551 | 0.3871 |
Echinococcus granulosus | geminin | 0.0377 | 0.5046 | 0.5029 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0155 | 0.1687 | 0.1535 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0705 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0343 | 0.4537 | 0.4437 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0308 | 0.4008 | 1 |
Toxoplasma gondii | aminopeptidase N protein | 0.0347 | 0.4589 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0046 | 0.0033 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0308 | 0.4008 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0347 | 0.4589 | 1 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0347 | 0.4589 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0146 | 0.1551 | 0.3871 |
Echinococcus granulosus | snurportin 1 | 0.0343 | 0.4537 | 0.4519 |
Brugia malayi | RNA, U transporter 1 | 0.0091 | 0.0727 | 0.3635 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0046 | 0.0033 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0179 | 0.0147 |
Loa Loa (eye worm) | acetyltransferase | 0.0155 | 0.1687 | 0.346 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0705 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0377 | 0.5046 | 0.4955 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0179 | 0.0147 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0347 | 0.4589 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0343 | 0.4537 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0308 | 0.4008 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.