Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0444 | 0.2645 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0444 | 0.2645 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0444 | 0.2645 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0444 | 0.2645 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0071 | 0.0322 | 0.2786 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1156 | 1 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0302 | 0.1762 | 0.2435 |
Brugia malayi | Carboxylesterase family protein | 0.0071 | 0.0322 | 0.0445 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1156 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0225 | 0.1949 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0225 | 0.1949 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0071 | 0.0322 | 0.2786 |
Brugia malayi | Carboxylesterase family protein | 0.0071 | 0.0322 | 0.0445 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0225 | 0.1949 |
Brugia malayi | Telomerase reverse transcriptase | 0.1181 | 0.7236 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.1156 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0071 | 0.0322 | 0.2786 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0444 | 0.2645 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0071 | 0.0322 | 0.2786 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0444 | 0.2645 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0225 | 0.0311 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0225 | 0.1949 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1156 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0225 | 0.1949 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0225 | 0.1949 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0444 | 0.2645 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0225 | 0.1278 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0071 | 0.0322 | 0.1828 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0444 | 0.2645 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0225 | 0.1949 |
Loa Loa (eye worm) | STAT protein | 0.0302 | 0.1762 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0071 | 0.0322 | 0.2786 |
Loa Loa (eye worm) | carboxylesterase | 0.0071 | 0.0322 | 0.1828 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0322 | 0.1828 |
Echinococcus granulosus | acetylcholinesterase | 0.0071 | 0.0322 | 0.2786 |
Echinococcus granulosus | carboxylesterase 5A | 0.0071 | 0.0322 | 0.2786 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0322 | 0.1828 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.2643 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.