Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Schistosoma mansoni | Thioredoxin glutathione reductase | Starlite/ChEMBL | No references |
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) | Human immunodeficiency virus type 1 Tat protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.1538 | 0.8342 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0426 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.1538 | 0.8342 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0426 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0426 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0426 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0426 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0 | 0.5 |
Onchocerca volvulus | Deterin homolog | 0.0426 | 1 | 0.5 |
Onchocerca volvulus | 0.0426 | 1 | 0.5 | |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.1538 | 0.8342 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0426 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.1844 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.1844 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 1 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.1538 | 0.8342 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.1538 | 0.8342 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.1538 | 0.8342 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.1844 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.1844 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0426 | 1 | 1 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0426 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0046 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 10.126 uM | PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.