Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.7327 | 0.7327 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.7327 | 0.7327 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.7327 | 0.7327 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.7327 | 0.7327 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.7327 | 0.7327 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.7327 | 0.7327 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 1 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 1 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.7327 | 0.7327 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.7327 | 0.7327 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.7327 | 0.7327 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.7327 | 0.7327 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.7327 | 0.7327 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 1 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.7327 | 0.7327 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 1 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.7327 | 0.7327 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.7327 | 0.7327 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.7327 | 0.7327 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12000 uM | In vitro inhibitory activity of the compound against human Cell division cycle 25A | ChEMBL. | 10498203 |
IC50 (binding) | = 12000 uM | In vitro inhibitory activity of the compound against human Cell division cycle 25A | ChEMBL. | 10498203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.