Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0188 | 0.1965 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0188 | 0.1965 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0188 | 0.1965 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0493 | 0.5763 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0493 | 0.5763 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0188 | 0.1965 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0188 | 0.1965 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.0493 | 0.5763 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0493 | 0.5763 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.0493 | 0.5763 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0188 | 0.1965 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0493 | 0.5763 | 0.5 |
Chlamydia trachomatis | peptide deformylase | 0.0493 | 0.5763 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0493 | 0.5763 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0493 | 0.5763 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0188 | 0.1965 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4125 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.