Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | carbohydrate phosphorylase | 0.0321 | 0.3419 | 0.9282 |
Schistosoma mansoni | glycogen phosphorylase | 0.0321 | 0.3419 | 0.3419 |
Schistosoma mansoni | glycogen phosphorylase | 0.0139 | 0.1075 | 0.1075 |
Echinococcus granulosus | glycogen phosphorylase | 0.0321 | 0.3419 | 0.3419 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0321 | 0.3419 | 0.9282 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0064 | 0.0173 |
Giardia lamblia | Glycogen phosphorylase | 0.0321 | 0.3419 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0139 | 0.1075 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0321 | 0.3419 | 0.3419 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0321 | 0.3419 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0321 | 0.3419 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0342 | 0.3683 | 0.3683 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0321 | 0.3419 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0321 | 0.3419 | 0.3419 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0321 | 0.3419 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0321 | 0.3419 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0064 | 0.0173 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0342 | 0.3683 | 0.3683 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0064 | 0.0173 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0342 | 0.3683 | 0.3683 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0321 | 0.3419 | 0.3419 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0321 | 0.3419 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0342 | 0.3683 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0342 | 0.3683 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0321 | 0.3419 | 0.3419 |
Schistosoma mansoni | glycogen phosphorylase | 0.0321 | 0.3419 | 0.3419 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0064 | 0.0173 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0139 | 0.1075 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0321 | 0.3419 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.