Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | segment polarity protein dishevelled | 0.0096 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.1748 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1748 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.1748 | 0.1748 |
Toxoplasma gondii | hypothetical protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1009 | 0.1009 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1748 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.1748 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.1009 | 0.139 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.1748 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.1748 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.1748 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0096 | 1 | 1 |
Brugia malayi | DIX domain containing protein | 0.0019 | 0.1015 | 0.1015 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.1748 | 1 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0055 | 0.5211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1009 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1748 | 0.1748 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.1748 | 0.1748 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.1748 | 0.1748 |
Schistosoma mansoni | dishevelled | 0.0096 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.1009 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.528 | 0.528 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.1748 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1748 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.528 | 0.528 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.1009 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.528 | 0.528 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.528 | 0.528 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.528 | 0.528 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0096 | 1 | 1 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.1009 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1748 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1748 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.528 | 0.528 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.528 | 0.528 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1748 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1009 | 0.1009 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.1748 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.528 | 0.528 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1009 | 0.1009 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.1748 | 1 |
Schistosoma mansoni | dishevelled | 0.0086 | 0.8825 | 0.8825 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1748 | 0.1748 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.528 | 0.528 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.1748 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1009 | 0.1009 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.1748 | 0.5 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0019 | 0.1015 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1748 | 0.1748 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.1748 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7943 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.