TDR Targets

Basic information

Technical information

TDR Targets ID: 1385628
Name: 1-naphthalen-1-ylethenylphosphonic acid
MW: 234.188 | Formula: C12H11O3P
H donors: 2 H acceptors: 3 LogP: 1.77 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: C=C(P(=O)(O)O)c1cccc2c1cccc2
InChi: 1S/C12H11O3P/c1-9(16(13,14)15)11-8-4-6-10-5-2-3-7-12(10)11/h2-8H,1H2,(H2,13,14,15)
InChiKey: ZDNBHAWXBDXUSP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(1-naphthyl)vinylphosphonic acid
Oprea1_166663
MLS000079039
STOCK1S-19117
SMR000038809

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Pseudomonas aeruginosa	Beta Lactamase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	class a beta-lactamase, BlaC	Get druggable targets OG5_143180	All targets in OG5_143180
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	Get druggable targets OG5_143180	All targets in OG5_143180
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Schistosoma mansoni	glycogen phosphorylase	0.0421	0.5985	0.5985
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Echinococcus granulosus	serotonin receptor	0.0051	0.0193	0.0193
Brugia malayi	G protein-coupled receptor	0.0051	0.0193	0.0255
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0244	0.3224	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.0626	0.0626
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0626	0.5
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	7tm_1 domain containing protein	0.0051	0.0193	0.0193
Brugia malayi	Pre-SET motif family protein	0.0251	0.3336	0.4418
Schistosoma mansoni	opsin-like receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	allatostatin A receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	hypothetical protein	0.0051	0.0193	0.0193
Onchocerca volvulus		0.0051	0.0193	0.0322
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0002	0.0003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0193	0.0193
Echinococcus multilocularis	somatostatin receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	neuropeptide receptor A26	0.0051	0.0193	0.0193
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0051	0.0193	0.0193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	orexin receptor type 2	0.0051	0.0193	0.0193
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0193	0.0193
Echinococcus multilocularis	G protein coupled receptor 139	0.0051	0.0193	0.0193
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0193	0.0193
Onchocerca volvulus		0.0051	0.0193	0.0322
Entamoeba histolytica	glycogen phosphorylase, putative	0.0421	0.5985	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0193	0.0322
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0204	0.3262
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.0204	0.0633
Brugia malayi	putative neuropeptide receptor	0.0051	0.0193	0.0255
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Schistosoma mansoni	adenoreceptor	0.0051	0.0193	0.0193
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0103	0.0103
Onchocerca volvulus		0.0051	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0626	0.1046
Brugia malayi	neuropeptide F receptor	0.0051	0.0193	0.0255
Echinococcus granulosus	fmrfamide receptor	0.0051	0.0193	0.0193
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0626	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0051	0.0193	0.0322
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Schistosoma mansoni	growth hormone secretagogue receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0193	0.0193
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	myosin xvIII	0.0051	0.0193	0.0193
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0051	0.0193	0.0255
Echinococcus granulosus	7TM GPCR rhodopsin	0.0051	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0051	0.0193	0.0255
Schistosoma mansoni	transient receptor potential channel 4	0.0103	0.1015	0.1015
Echinococcus multilocularis	glycogen phosphorylase	0.0421	0.5985	0.5985
Leishmania major	hypothetical protein, conserved	0.0038	0	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0193	0.0193
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0193	0.0193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0077	0.0606	0.9676
Entamoeba histolytica	glycogen phosphorylase, putative	0.0421	0.5985	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0051	0.0193	0.0193
Brugia malayi	Dopamine receptor	0.0051	0.0193	0.0255
Echinococcus multilocularis	allatostatin A receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0103	0.0103
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	transient receptor potential gamma protein	0.0103	0.1015	0.1015
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Brugia malayi	hypothetical protein	0.0051	0.0193	0.0255
Schistosoma mansoni	amine GPCR	0.0051	0.0193	0.0193
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	short transient receptor potential channel 6	0.0068	0.0469	0.0469
Schistosoma mansoni	hypothetical protein	0.0051	0.0193	0.0193
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0051	0.0193	0.0193
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0182	0.2248	1
Echinococcus multilocularis	transient receptor potential gamma protein	0.0103	0.1015	0.1015
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0	0.5
Brugia malayi	Melatonin receptor type 1A	0.0051	0.0193	0.0255
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0051	0.0193	0.0193
Brugia malayi	sulfakinin receptor protein	0.0051	0.0193	0.0255
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0193	0.0193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Echinococcus multilocularis	serotonin receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0051	0.0193	0.0322
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0051	0.0193	0.0193
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.0626	0.0626
Schistosoma mansoni	transient receptor potential channel	0.0068	0.0469	0.0469
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0193	0.0193
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0051	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0193	0.0193
Echinococcus granulosus	neuropeptide s receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0204	0.0204
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0193	0.0193
Brugia malayi	larval opioid receptor	0.0051	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0193	0.0193
Echinococcus multilocularis	neuropeptide receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	transient receptor potential ion channel A	0.01	0.0961	0.0961
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	g-protein coupled receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	glycogen phosphorylase	0.0421	0.5985	0.5985
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	orexin receptor type 2	0.0051	0.0193	0.0193
Brugia malayi	neuropeptide F receptor	0.0051	0.0193	0.0255
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0051	0.0193	0.0193
Onchocerca volvulus		0.0051	0.0193	0.0322
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.3336	0.5573
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0051	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0051	0.0193	0.0255
Onchocerca volvulus		0.0051	0.0193	0.0322
Brugia malayi	Serotonin receptor	0.0521	0.7551	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Echinococcus granulosus	Glycosyl transferase family 35	0.0421	0.5985	0.5985
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0182	0.2248	0.6973
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0626	0.2785
Echinococcus granulosus	neuropeptide FF receptor 2	0.0051	0.0193	0.0193
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.0626	1
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	neuropeptide receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0193	0.0193
Chlamydia trachomatis	glycogen phosphorylase	0.0421	0.5985	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	neuropeptide receptor	0.0051	0.0193	0.0193
Onchocerca volvulus		0.0051	0.0193	0.0322
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0204	0.0204
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0193	0.0193
Brugia malayi	Dopamine receptor protein 2	0.0051	0.0193	0.0255
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0051	0.0193	0.0193
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0421	0.5985	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0415	0.0693
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0051	0.0193	0.0322
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1015	0.1695
Echinococcus multilocularis	transient receptor potential ion channel A	0.01	0.0961	0.0961
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0193	0.0193
Brugia malayi	carbohydrate phosphorylase	0.0421	0.5985	0.7927
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0626	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	short transient receptor potential channel 6	0.0068	0.0469	0.0469
Echinococcus multilocularis	serotonin receptor	0.0051	0.0193	0.0193
Brugia malayi	ORL1-like opioid receptor	0.0051	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Brugia malayi	G protein-coupled receptor F59B2.13	0.0051	0.0193	0.0255
Loa Loa (eye worm)	melatonin receptor type 1A	0.0051	0.0193	0.0322
Echinococcus multilocularis	neuropeptide s receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.0626	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus multilocularis	dro:myosuppressin receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	glycogen phosphorylase	0.0421	0.5985	0.5985
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.3879	0.6481
Echinococcus granulosus	hypothetical protein	0.0051	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0051	0.0193	0.0255
Brugia malayi	G-protein coupled receptor	0.0051	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0051	0.0193	0.0193
Schistosoma mansoni	histamine h1 receptor	0.0051	0.0193	0.0193
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0051	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	G protein coupled receptor 139	0.0051	0.0193	0.0193
Onchocerca volvulus		0.0051	0.0193	0.0322
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0193	0.0193
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0051	0.0193	0.0322
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0051	0.0193	0.0322
Brugia malayi	hypothetical protein	0.0051	0.0193	0.0255
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0051	0.0193	0.0255
Loa Loa (eye worm)	TYRA-2 protein	0.0051	0.0193	0.0322
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0193	0.0193
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0421	0.5985	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0051	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0051	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Brugia malayi	AKH receptor	0.0051	0.0193	0.0255
Brugia malayi	Probable ClpP-like protease	0.0078	0.0626	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.016	0.191	0.8496
Echinococcus multilocularis	g-protein coupled receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0051	0.0193	0.0193
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0077	0.0606	0.1879
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0103	0.0171
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0051	0.0193	0.0193
Loa Loa (eye worm)	glycogen phosphorylase	0.0421	0.5985	1
Echinococcus granulosus	sex peptide receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0051	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0051	0.0193	0.0255
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	neuropeptide receptor A26	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Brugia malayi	Dopamine receptor protein 1	0.0051	0.0193	0.0255
Onchocerca volvulus		0.0051	0.0193	0.0322
Onchocerca volvulus		0.0286	0.3879	0.6481
Onchocerca volvulus		0.0051	0.0193	0.0322
Schistosoma mansoni	transient receptor potential channel	0.0068	0.0469	0.0469
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0051	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0051	0.0193	0.0255
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0051	0.0193	0.0193
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0421	0.5985	0.5985
Schistosoma mansoni	opsin-like receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0193	0.0322
Onchocerca volvulus		0.0051	0.0193	0.0322
Echinococcus multilocularis	glycogen phosphorylase	0.0421	0.5985	0.5985
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0103	0.0103
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0193	0.0193
Brugia malayi	G-protein coupled receptor	0.0051	0.0193	0.0255
Echinococcus multilocularis	short transient receptor potential channel 6	0.0068	0.0469	0.0469
Brugia malayi	RE15519p	0.0051	0.0193	0.0255
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Echinococcus granulosus	glycogen phosphorylase	0.0421	0.5985	0.5985
Schistosoma mansoni	hypothetical protein	0.0051	0.0193	0.0193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0103	0.0136
Brugia malayi	hypothetical protein	0.0051	0.0193	0.0255
Brugia malayi	Serotonin receptor	0.0051	0.0193	0.0255
Brugia malayi	follicle stimulating hormone receptor	0.0051	0.0193	0.0255
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	TRP transient receptor potential channel	0.0038	0.0002	0.0002
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0193	0.0193
Mycobacterium ulcerans	lipoprotein LpqF	0.0077	0.0606	0.2694
Schistosoma mansoni	transient receptor potential channel	0.0103	0.1015	0.1015
Giardia lamblia	Glycogen phosphorylase	0.0421	0.5985	0.5
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0193	0.0322
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	opsin-like receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0626	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0051	0.0193	0.0193
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Onchocerca volvulus		0.0051	0.0193	0.0322
Echinococcus multilocularis	sex peptide receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0051	0.0193	0.0193
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	neuropeptide receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	amine GPCR	0.0051	0.0193	0.0193
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.016	0.191	0.5925
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Brugia malayi	GnHR receptor homolog	0.0051	0.0193	0.0255
Schistosoma mansoni	hypothetical protein	0.0051	0.0193	0.0193
Brugia malayi	putative neuropeptide receptor NPR1	0.0051	0.0193	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0051	0.0193	0.0255
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0193	0.0193
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0193	0.0193
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0626	0.2785
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.0626	1
Trypanosoma brucei	beta lactamase	0.0077	0.0606	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0626	1
Schistosoma mansoni	amine GPCR	0.0051	0.0193	0.0193
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0193	0.0193
Onchocerca volvulus		0.0051	0.0193	0.0322
Onchocerca volvulus		0.0051	0.0193	0.0322
Onchocerca volvulus		0.0051	0.0193	0.0322
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0193	0.0193
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0421	0.5985	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	short transient receptor potential channel 6	0.0068	0.0469	0.0469
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0051	0.0193	0.0255
Schistosoma mansoni	glycogen phosphorylase	0.0182	0.2248	0.2248
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0193	0.0193
Schistosoma mansoni	amine GPCR	0.0051	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0051	0.0193	0.0255
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0193	0.0193
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	amine GPCR	0.0051	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus multilocularis	microtubule associated protein 2	0.0677	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0193	0.0322
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0051	0.0193	0.0193
Schistosoma mansoni	microtubule-associated protein tau	0.0677	1	1
Brugia malayi	Transient-receptor-potential like protein	0.0038	0.0002	0.0002
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0038	0.0002	0.0002
Onchocerca volvulus		0.0051	0.0193	0.0322
Echinococcus granulosus	somatostatin receptor	0.0051	0.0193	0.0193
Onchocerca volvulus		0.0051	0.0193	0.0322
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.0204	0.0633
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0051	0.0193	0.0255
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0193	0.0193
Onchocerca volvulus		0.0051	0.0193	0.0322
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0193	0.0322

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.165 uM	PubChem BioAssay. FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify epi-absorbance assay artifacts. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (binding)	= 6.811 uM	PubChem BioAssay. Epi-absorbance-based dose response biochemical high throughput screening assay for selective inhibitors of VIM-2 metallo-beta-lactamase. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (binding)	= 26.98 um	PUBCHEM_BIOASSAY: TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2). (Class of assay: confirmatory) [Related pubchem assays: 794, 727, 810 ]	ChEMBL.	No reference
IC50 (binding)	> 59.64 uM	PubChem BioAssay. Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of TEM-1 serine-beta-lactamase. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (binding)	> 59.64 uM	PubChem BioAssay. FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (binding)	> 59.64 uM	PubChem BioAssay. Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.8526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	33.8078 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1538815

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1385628