Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0615 | 0.0416 | 1 |
Toxoplasma gondii | hypothetical protein | 0.9274 | 1 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0375 | 0.015 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.9274 | 1 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3539 | 0.3651 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3539 | 0.3651 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.0384 | 0.0159 | 0.3812 |
Echinococcus granulosus | adam 17 protease | 0.0422 | 0.0201 | 0.4832 |
Plasmodium falciparum | peptide deformylase | 0.9274 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3539 | 0.3651 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.9274 | 1 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0375 | 0.015 | 1 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0384 | 0.0159 | 1 |
Brugia malayi | Matrixin family protein | 0.0409 | 0.0187 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.9274 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0409 | 0.0187 | 0.0786 |
Mycobacterium ulcerans | peptide deformylase | 0.9274 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.9274 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.9274 | 1 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3539 | 0.3651 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3539 | 0.3651 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3539 | 0.3651 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3539 | 0.3651 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0615 | 0.0416 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.0626 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2617 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 1.5849 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.