Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 1 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0193 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0136 | 0.4985 | 0.4985 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.4985 | 0.4985 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0136 | 0.4985 | 0.4985 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0132 | 0.463 | 0.463 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0193 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0193 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0193 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0193 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0136 | 0.4985 | 0.4985 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0193 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0114 | 0.2979 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0132 | 0.463 | 0.463 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0193 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0132 | 0.463 | 0.463 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0136 | 0.4985 | 0.4985 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0193 | 1 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0132 | 0.463 | 0.463 |
Onchocerca volvulus | 0.0193 | 1 | 1 | |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0193 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0132 | 0.463 | 0.463 |
Trypanosoma brucei | prolyl endopeptidase | 0.0136 | 0.4985 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0136 | 0.4985 | 0.4985 |
Echinococcus granulosus | prolyl endopeptidase | 0.0136 | 0.4985 | 0.4985 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0136 | 0.4985 | 0.4985 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0132 | 0.463 | 0.463 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4125 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.