Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0241 | 0.1747 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0596 | 0.5455 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0241 | 0.1747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0977 | 0.5592 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.103 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.103 | 1 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0241 | 0.1747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0977 | 0.5592 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0241 | 0.1747 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0241 | 0.1747 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0241 | 0.1747 | 0.1747 |
Leishmania major | DNA topoisomerase ii | 0.0167 | 0.0977 | 0.1791 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.103 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0596 | 0.5455 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.103 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.103 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.103 | 1 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0241 | 0.1747 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0208 | 0.1409 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0355 | 0.2938 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0241 | 0.1747 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0596 | 0.5455 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0241 | 0.1747 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0241 | 0.1747 | 0.3202 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0167 | 0.0977 | 0.1791 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0241 | 0.1747 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0241 | 0.1747 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0676 | 0.6292 | 0.6292 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0167 | 0.0977 | 0.1791 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0167 | 0.0977 | 0.1791 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0596 | 0.5455 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0167 | 0.0977 | 0.1791 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0241 | 0.1747 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0241 | 0.1747 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0596 | 0.5455 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0241 | 0.1747 | 0.1747 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.6573 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.4716 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 1.5849 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.