Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0067 | 0.4877 | 0.5 | |
Echinococcus granulosus | jun protein | 0.0086 | 1 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0086 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0086 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.5531 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.007 | 0.5531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0067 | 0.4877 | 0.4877 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0086 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.9346 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.