Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2405 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0109 | 0.2405 | 0.5 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0126 | 0.3195 | 1 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0126 | 0.3195 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0109 | 0.2405 | 0.7526 |
Giardia lamblia | Kinase, PLK | 0.0109 | 0.2405 | 0.5 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0126 | 0.3195 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0109 | 0.2405 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0109 | 0.2405 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2405 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0109 | 0.2405 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2405 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2405 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2405 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0109 | 0.2405 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2405 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0109 | 0.2405 | 0.5 |
Toxoplasma gondii | MAPEG family protein | 0.0126 | 0.3195 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.2405 | 0.5 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0126 | 0.3195 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0109 | 0.2405 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0109 | 0.2405 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.