Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0773 | 0.5784 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0437 | 0.2725 | 0.4303 |
Schistosoma mansoni | glycogen phosphorylase | 0.0437 | 0.2725 | 0.2725 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0437 | 0.2725 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0189 | 0.0464 | 0.0464 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0225 | 0.0788 | 0.0788 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0773 | 0.5784 | 0.9132 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0437 | 0.2725 | 0.4303 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0437 | 0.2725 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0773 | 0.5784 | 0.9132 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.6334 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0773 | 0.5784 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0189 | 0.0464 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.6334 | 0.6334 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0437 | 0.2725 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0437 | 0.2725 | 0.2725 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0773 | 0.5784 | 0.5784 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0437 | 0.2725 | 0.4303 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0437 | 0.2725 | 0.4712 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.6334 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0437 | 0.2725 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0437 | 0.2725 | 0.4303 |
Brugia malayi | carbohydrate phosphorylase | 0.0437 | 0.2725 | 0.4712 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0189 | 0.0464 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0437 | 0.2725 | 0.4303 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0437 | 0.2725 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0437 | 0.2725 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0437 | 0.2725 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0437 | 0.2725 | 0.4303 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.