Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0175 | 0.5132 | 0.5 |
Mycobacterium ulcerans | DNA polymerase I | 0.0054 | 0.0592 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0222 | 0.6872 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.011 | 0.2661 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0175 | 0.5132 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0083 | 0.1675 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0054 | 0.0592 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0083 | 0.1675 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0083 | 0.1675 | 0.5 |
Chlamydia trachomatis | DNA polymerase I | 0.0054 | 0.0592 | 0.5 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0175 | 0.5132 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0175 | 0.5132 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0083 | 0.1675 | 0.5 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0175 | 0.5132 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0175 | 0.5132 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.011 | 0.2661 | 1 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0175 | 0.5132 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.1675 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0083 | 0.1675 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.011 | 0.2661 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.0175 | 0.5132 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0083 | 0.1675 | 1 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.011 | 0.2661 | 1 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0175 | 0.5132 | 0.744 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0175 | 0.5132 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0054 | 0.0592 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0054 | 0.0592 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.1675 | 1 |
Treponema pallidum | DNA polymerase I (polA) | 0.0054 | 0.0592 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 2.4 ug ml-1 | In vitro growth inhibitory effect of the compound against L1210 murine leukemia cells was determined | ChEMBL. | 4020835 |
ID50 (functional) | = 2.4 ug ml-1 | In vitro growth inhibitory effect of the compound against L1210 murine leukemia cells was determined | ChEMBL. | 4020835 |
T/C (functional) | 0 % | Activity of the compound against L1210 leukemia cells was studied in mice at 100 mg/kg and determined as MST(treated)/MST(control) x100; Toxic | ChEMBL. | 4020835 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.