Detailed information for compound 1397896

Basic information

Technical information
  • TDR Targets ID: 1397896
  • Name: 1-[3-[4-(2-methylphenyl)piperazin-1-yl]piperi din-1-yl]-3-(1,2-oxazolidin-2-yl)propan-1-one
  • MW: 386.531 | Formula: C22H34N4O2
  • H donors: 0 H acceptors: 1 LogP: 2.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCC(C1)N1CCN(CC1)c1ccccc1C)CCN1CCCO1
  • InChi: 1S/C22H34N4O2/c1-19-6-2-3-8-21(19)24-15-13-23(14-16-24)20-7-4-10-25(18-20)22(27)9-12-26-11-5-17-28-26/h2-3,6,8,20H,4-5,7,9-18H2,1H3
  • InChiKey: SMKCMZMUVYBCTD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-isoxazolidin-2-yl-1-[3-[4-(2-methylphenyl)piperazin-1-yl]-1-piperidyl]propan-1-one
  • 3-(2-isoxazolidinyl)-1-[3-[4-(2-methylphenyl)-1-piperazinyl]-1-piperidinyl]propan-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.021 0.0153
Echinococcus multilocularis snurportin 1 0.0299 0.3013 0.2972
Brugia malayi hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni amine GPCR 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus granulosus serotonin receptor 0.0042 0.021 0.0153
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni neuropeptide receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.021 0.0153
Brugia malayi RNA, U transporter 1 0.008 0.0621 0.0566
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.021 0.0153
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni amine GPCR 0.0042 0.021 0.0153
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.021 0.0153
Echinococcus granulosus hypothetical protein 0.0042 0.021 0.0153
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.021 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.021 0.0153
Brugia malayi hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.021 0.0153
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.021 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.021 0.0153
Brugia malayi GnHR receptor homolog 0.0042 0.021 0.0153
Brugia malayi neuropeptide F receptor 0.0042 0.021 0.0153
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.021 0.0153
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.021 0.0153
Schistosoma mansoni opsin-like receptor 0.0042 0.021 0.0153
Brugia malayi hypothetical protein 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Schistosoma mansoni opsin-like receptor 0.0042 0.021 0.0153
Schistosoma mansoni biogenic amine receptor 0.0042 0.021 0.0153
Echinococcus multilocularis serotonin receptor 0.0042 0.021 0.0153
Echinococcus multilocularis orexin receptor type 2 0.0042 0.021 0.0153
Mycobacterium ulcerans hypothetical protein 0.0411 0.4226 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.021 0.0153
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.021 0.0153
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.021 0.0153
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.021 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.021 0.0153
Echinococcus granulosus sex peptide receptor 0.0042 0.021 0.0153
Echinococcus granulosus neuropeptide receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.021 0.0153
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.021 0.0153
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.021 0.0153
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.021 0.0153
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.021 0.0153
Schistosoma mansoni biogenic amine receptor 0.0042 0.021 0.0153
Echinococcus granulosus g protein coupled receptor 0.0042 0.021 0.0153
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.021 0.0153
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.021 0.0153
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Brugia malayi ORL1-like opioid receptor 0.0042 0.021 0.0153
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.021 0.0153
Schistosoma mansoni amine GPCR 0.0042 0.021 0.0153
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.021 0.0153
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.021 0.0153
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.021 0.0153
Echinococcus multilocularis g protein coupled receptor 0.0042 0.021 0.0153
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.021 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.021 0.0153
Brugia malayi G-protein coupled receptor 0.0042 0.021 0.0153
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.021 0.0153
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.021 0.0153
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Onchocerca volvulus 0.0042 0.021 0.5
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0411 0.4226 0.5
Echinococcus granulosus g protein coupled receptor 0.0042 0.021 0.0153
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.021 0.0153
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.021 0.0153
Echinococcus multilocularis somatostatin receptor 0.0042 0.021 0.0153
Schistosoma mansoni neuropeptide receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni amine GPCR 0.0042 0.021 0.0153
Brugia malayi hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni hypothetical protein 0.0042 0.021 0.0153
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.021 0.0153
Brugia malayi Serotonin receptor 0.0042 0.021 0.0153
Echinococcus multilocularis g protein coupled receptor 0.0042 0.021 0.0153
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.021 0.0153
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.021 0.0153
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.021 0.0153
Echinococcus multilocularis sex peptide receptor 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.021 0.0153
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.021 0.0153
Echinococcus granulosus somatostatin receptor 0.0042 0.021 0.0153
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Brugia malayi hypothetical protein 0.0042 0.021 0.0153
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.021 0.0153
Echinococcus multilocularis fmrfamide receptor 0.0042 0.021 0.0153
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni opsin-like receptor 0.0042 0.021 0.0153
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.021 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.021 0.0153
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.021 0.0153
Brugia malayi sulfakinin receptor protein 0.0042 0.021 0.0153
Schistosoma mansoni neuropeptide receptor 0.0042 0.021 0.0153
Echinococcus multilocularis g protein coupled receptor 0.0042 0.021 0.0153
Schistosoma mansoni myosin xvIII 0.0042 0.021 0.0153
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.021 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.021 0.0153
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Brugia malayi Dopamine receptor 0.0042 0.021 0.0153
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.021 0.0153
Brugia malayi Serotonin receptor 0.0042 0.021 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Brugia malayi neuropeptide F receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.021 0.0153
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.021 0.0153
Brugia malayi G-protein coupled receptor 0.0042 0.021 0.0153
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Schistosoma mansoni neuropeptide receptor 0.0042 0.021 0.0153
Brugia malayi hypothetical protein 0.0042 0.021 0.0153
Brugia malayi Dopamine receptor protein 2 0.0042 0.021 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.021 0.0153
Echinococcus granulosus orexin receptor type 2 0.0042 0.021 0.0153
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.021 0.0153
Echinococcus granulosus fmrfamide receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.021 0.0153
Brugia malayi follicle stimulating hormone receptor 0.0042 0.021 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.021 0.0153
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Brugia malayi hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.3013 0.2972
Brugia malayi Melatonin receptor type 1A 0.0042 0.021 0.0153
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.021 0.0153
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.021 0.0153
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.021 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.021 0.0153
Schistosoma mansoni hypothetical protein 0.0042 0.021 0.0153
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.021 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Schistosoma mansoni biogenic amine receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus multilocularis neuropeptide receptor 0.0042 0.021 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus granulosus g protein coupled receptor 0.0042 0.021 0.0153
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.021 0.0153
Echinococcus multilocularis allatostatin A receptor 0.0042 0.021 0.0153
Echinococcus multilocularis fmrfamide receptor 0.0042 0.021 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.021 0.0153
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.021 0.0153
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.021 0.0153
Brugia malayi AKH receptor 0.0042 0.021 0.0153
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.021 0.0153
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.021 0.0153
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Brugia malayi putative neuropeptide receptor 0.0042 0.021 0.0153
Echinococcus multilocularis serotonin receptor 0.0042 0.021 0.0153
Brugia malayi hypothetical protein 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Brugia malayi Dopamine receptor protein 1 0.0042 0.021 0.0153
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.021 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.021 0.0153
Schistosoma mansoni histamine h1 receptor 0.0042 0.021 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Echinococcus granulosus g-protein coupled receptor 0.0042 0.021 0.0153
Schistosoma mansoni hypothetical protein 0.0299 0.3013 0.2972
Brugia malayi hypothetical protein 0.0042 0.021 0.0153
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.021 0.0153
Echinococcus granulosus neuropeptide receptor 0.0042 0.021 0.0153
Brugia malayi larval opioid receptor 0.0042 0.021 0.0153
Echinococcus granulosus allatostatin A receptor 0.0042 0.021 0.0153
Brugia malayi RE15519p 0.0042 0.021 0.0153
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Loa Loa (eye worm) hypothetical protein 0.0042 0.021 0.0153
Brugia malayi G protein-coupled receptor 0.0042 0.021 0.0153
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.021 0.0153
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.021 0.0153
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.021 0.0153
Onchocerca volvulus 0.0042 0.021 0.5
Echinococcus granulosus neuropeptide s receptor 0.0042 0.021 0.0153
Echinococcus multilocularis neuropeptide receptor 0.0042 0.021 0.0153
Schistosoma mansoni hypothetical protein 0.0042 0.021 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.021 0.0153
Schistosoma mansoni amine GPCR 0.0042 0.021 0.0153
Schistosoma mansoni adenoreceptor 0.0042 0.021 0.0153
Echinococcus granulosus snurportin 1 0.0299 0.3013 0.2972
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.021 0.0153
Brugia malayi hypothetical protein 0.0042 0.021 0.0153
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.021 0.0153
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.021 0.0153
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.021 0.0153
Schistosoma mansoni hypothetical protein 0.0042 0.021 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.021 0.0153

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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