Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.5296 | 0.5296 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0237 | 0.0237 |
Brugia malayi | DNA polymerase family B containing protein | 0.014 | 0.1992 | 0.1992 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0188 | 0.3344 | 0.1688 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.014 | 0.1992 | 0.1797 |
Trichomonas vaginalis | DNA polymerase delta catalytic subunit, putative | 0.014 | 0.1992 | 0.1797 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.014 | 0.1992 | 0.1992 |
Brugia malayi | DNA polymerase family B, exonuclease domain containing protein | 0.014 | 0.1992 | 0.1992 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.014 | 0.1992 | 0.1797 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.0904 | 0.0904 |
Schistosoma mansoni | DNA polymerase zeta catalytic subunit | 0.014 | 0.1992 | 0.1992 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0188 | 0.3344 | 0.1688 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.0904 | 0.0904 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1992 | 0.1992 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.014 | 0.1992 | 0.1797 |
Schistosoma mansoni | DNA polymerase epsilon catalytic subunit | 0.014 | 0.1992 | 0.1992 |
Loa Loa (eye worm) | DNA polymerase epsilon catalytic subunit | 0.0078 | 0.0237 | 0.0237 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.0346 | 0.7811 | 0.7266 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.014 | 0.1992 | 0.1992 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0257 | 0.5296 | 0.5296 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0237 | 0.0237 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.