Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0038 | 0.0038 |
Schistosoma mansoni | high voltage-activated calcium channel beta subunit 2 | 0.0325 | 0.4388 | 1 |
Schistosoma mansoni | serine-rich repeat protein | 0.0065 | 0.015 | 0.0259 |
Loa Loa (eye worm) | calcium channel | 0.0058 | 0.0038 | 0.0038 |
Echinococcus granulosus | high voltage activated calcium channel beta | 0.0325 | 0.4388 | 1 |
Echinococcus multilocularis | high voltage activated calcium channel beta | 0.0325 | 0.4388 | 1 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0058 | 0.0038 | 0.0038 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0061 | 0.0083 | 0.0105 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0275 | 0.3578 | 0.8137 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0275 | 0.3578 | 0.8137 |
Echinococcus multilocularis | geminin | 0.0205 | 0.2426 | 0.5489 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2426 | 0.5489 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0125 | 0.1135 | 0.2524 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.015 | 0.0259 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0125 | 0.1135 | 0.2524 |
Echinococcus granulosus | geminin | 0.0205 | 0.2426 | 0.5489 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2426 | 0.5489 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.012 | 0.1052 | 0.2332 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.0596 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.