Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.1939 | 0.261 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1939 | 0.261 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.1939 | 0.261 | 0.5 |
Giardia lamblia | Transglutaminase/protease, putative | 0.1939 | 0.261 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1939 | 0.261 | 0.5 |
Brugia malayi | Thioredoxin family protein | 0.1939 | 0.261 | 0.5 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.1939 | 0.261 | 0.5 |
Mycobacterium tuberculosis | Long conserved protein | 0.1939 | 0.261 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.1939 | 0.261 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.1939 | 0.261 | 0.5 |
Echinococcus multilocularis | Transglutaminase | 0.1939 | 0.261 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1939 | 0.261 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1939 | 0.261 | 1 |
Echinococcus granulosus | Transglutaminase | 0.1939 | 0.261 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.1939 | 0.261 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1939 | 0.261 | 0.5 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.1939 | 0.261 | 0.5 |
Mycobacterium ulcerans | transglutaminase family protein | 0.1939 | 0.261 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.