Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Schistosoma mansoni | Thioredoxin glutathione reductase | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Conserved hypothetical protein | 0.1716 | 0.4102 | 1 |
Giardia lamblia | Transglutaminase/protease, putative | 0.1716 | 0.4102 | 0.5 |
Mycobacterium ulcerans | transglutaminase family protein | 0.1716 | 0.4102 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1716 | 0.4102 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1716 | 0.4102 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.1716 | 0.4102 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1716 | 0.4102 | 1 |
Echinococcus multilocularis | Transglutaminase | 0.1716 | 0.4102 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.0144 | 0.035 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.1716 | 0.4102 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0023 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.1716 | 0.4102 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.0172 | 0.0072 |
Echinococcus multilocularis | geminin | 0.0182 | 0.0335 | 0.0812 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0023 | 0.0054 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.0144 | 0.035 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1716 | 0.4102 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0023 | 0.0054 |
Giardia lamblia | Hypothetical protein | 0.1716 | 0.4102 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0023 | 0.0057 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.0172 | 0.042 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.0335 | 0.0763 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.0144 | 0.035 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.0335 | 0.0763 |
Echinococcus granulosus | geminin | 0.0182 | 0.0335 | 0.0812 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.0144 | 0.035 |
Brugia malayi | Thioredoxin family protein | 0.1716 | 0.4102 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.0144 | 0.035 |
Echinococcus granulosus | Transglutaminase | 0.1716 | 0.4102 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.0144 | 0.035 |
Mycobacterium tuberculosis | Long conserved protein | 0.1716 | 0.4102 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.0172 | 0.042 |
Mycobacterium leprae | Conserved hypothetical protein | 0.1716 | 0.4102 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.1716 | 0.4102 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.0172 | 0.042 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0023 | 0.0054 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.1716 | 0.4102 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0023 | 0.0054 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.7783 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.7865 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.