Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 15-lipoxygenase | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | arachidonate 15-lipoxygenase | 662 aa | 590 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0077 | 0.2586 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0028 | 0.0195 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0077 | 0.2586 | 1 |
Brugia malayi | Amidase family protein | 0.0028 | 0.0195 | 0.0195 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.2586 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0077 | 0.2586 | 1 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0077 | 0.2586 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0077 | 0.2586 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0077 | 0.2586 | 1 |
Plasmodium vivax | PST-A protein | 0.0077 | 0.2586 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0067 | 0.2069 | 0.2069 |
Loa Loa (eye worm) | amidase | 0.0028 | 0.0195 | 0.0195 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0028 | 0.0195 | 0.0756 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0077 | 0.2586 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0028 | 0.0195 | 0.0195 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0077 | 0.2586 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0067 | 0.2069 | 0.2069 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0028 | 0.0195 | 0.0195 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0028 | 0.0195 | 0.0195 |
Plasmodium falciparum | lysophospholipase, putative | 0.0077 | 0.2586 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0077 | 0.2586 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0077 | 0.2586 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0077 | 0.2586 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0067 | 0.2069 | 0.2069 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0028 | 0.0195 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0077 | 0.2586 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0077 | 0.2586 | 1 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0077 | 0.2586 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0077 | 0.2586 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0028 | 0.0195 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.2586 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0077 | 0.2586 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0077 | 0.2586 | 0.5 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0028 | 0.0195 | 0.0195 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0028 | 0.0195 | 0.0195 |
Brugia malayi | putative amidase | 0.0028 | 0.0195 | 0.0195 |
Brugia malayi | Amidase family protein | 0.0028 | 0.0195 | 0.0195 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0028 | 0.0195 | 0.0195 |
Mycobacterium ulcerans | hypothetical protein | 0.0077 | 0.2586 | 1 |
Loa Loa (eye worm) | amidase | 0.0028 | 0.0195 | 0.0195 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0077 | 0.2586 | 0.5 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0028 | 0.0195 | 0.0756 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.