Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0216 | 0.5281 | 0.5 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0147 | 0.261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.1654 | 0.0427 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.7679 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0112 | 0.1281 | 0.491 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0147 | 0.261 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0147 | 0.261 | 1 |
Echinococcus granulosus | caspase 2 | 0.0112 | 0.1281 | 0.491 |
Echinococcus multilocularis | caspase | 0.0147 | 0.261 | 1 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0147 | 0.261 | 1 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0216 | 0.5281 | 0.5 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.0216 | 0.5281 | 0.5 |
Leishmania major | ferric reductase, putative | 0.0216 | 0.5281 | 0.5 |
Echinococcus granulosus | caspase | 0.0147 | 0.261 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.5733 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 63.0957 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.