Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0663 | 0.0663 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.4314 | 0.4314 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.4314 | 0.4314 |
Brugia malayi | Fibroblast growth factor family protein | 0.0134 | 0.4314 | 0.4314 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0663 | 0.0663 |
Brugia malayi | Fibroblast growth factor family protein | 0.0134 | 0.4314 | 0.4314 |
Giardia lamblia | Hypothetical protein | 0.0134 | 0.4314 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.