Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide S receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | neuropeptide receptor A26 | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Schistosoma japonicum | IPR000276,Rhodopsin-like GPCR superfamily,domain-containing | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus multilocularis | neuropeptide receptor A26 | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus granulosus | neuropeptide s receptor | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus multilocularis | neuropeptide s receptor | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0552 | 0.974 | 1 |
Onchocerca volvulus | 0.0552 | 0.974 | 1 | |
Onchocerca volvulus | 0.0552 | 0.974 | 1 | |
Onchocerca volvulus | 0.0552 | 0.974 | 1 | |
Onchocerca volvulus | 0.0552 | 0.974 | 1 | |
Onchocerca volvulus | 0.0552 | 0.974 | 1 | |
Onchocerca volvulus | 0.0552 | 0.974 | 1 | |
Onchocerca volvulus | 0.0552 | 0.974 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0552 | 0.974 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0552 | 0.974 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0552 | 0.974 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0552 | 0.974 | 1 |
Onchocerca volvulus | 0.0552 | 0.974 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 141.2538 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.