Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.3193 | 0.3193 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.4457 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4457 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4457 | 1 |
Brugia malayi | TAR-binding protein | 0.007 | 0.4457 | 0.4457 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.3193 | 0.3193 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1715 | 0.1715 |
Brugia malayi | RNA binding protein | 0.007 | 0.4457 | 0.4457 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3193 | 0.3193 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1715 | 0.1715 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4457 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.3193 | 0.3193 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4457 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.4457 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.4457 | 0.4457 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.4457 | 0.4457 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.4457 | 0.4457 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4457 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.4457 | 0.4457 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1715 | 0.3848 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3981 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.