Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0213 | 0.2447 | 1 |
Trypanosoma brucei | squalene synthase, putative | 0.0362 | 0.4508 | 0.5 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0213 | 0.2447 | 0.7083 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.2447 | 0.8225 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.3455 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.2975 | 1 |
Leishmania major | squalene synthase, putative | 0.0362 | 0.4508 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0362 | 0.4508 | 1 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0213 | 0.2447 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.2975 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0362 | 0.4508 | 1 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0213 | 0.2447 | 1 |
Onchocerca volvulus | 0.0286 | 0.3455 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.