Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0503 | 0.0503 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0191 | 0.1071 | 0.1071 |
Echinococcus granulosus | glutamine synthetase | 0.0222 | 0.2678 | 0.2678 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1071 | 0.1071 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0191 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0191 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0191 | 0.1071 | 0.1071 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.0503 | 0.0503 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0222 | 0.2678 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.0503 | 0.0503 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0191 | 0.1071 | 0.1071 |
Echinococcus multilocularis | glutamine synthetase | 0.0222 | 0.2678 | 0.2678 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0222 | 0.2678 | 0.5 |
Brugia malayi | hypothetical protein | 0.0191 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1071 | 0.1071 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.0503 | 0.0503 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.6002 | 0.6002 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.6002 | 0.6002 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0191 | 0.1071 | 0.1071 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.0503 | 0.0503 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0191 | 0.1071 | 0.1071 |
Brugia malayi | nuclear receptor RXR | 0.0191 | 0.1071 | 0.1071 |
Schistosoma mansoni | glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) | 0.0222 | 0.2678 | 0.2678 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.6002 | 0.6002 |
Brugia malayi | hypothetical protein | 0.0286 | 0.6002 | 0.6002 |
Trypanosoma brucei | glutamine synthetase, putative | 0.0222 | 0.2678 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0191 | 0.1071 | 0.1071 |
Leishmania major | glutamine synthetase, putative | 0.0222 | 0.2678 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0503 | 0.0503 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 17.7828 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.