Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0347 | 0.0512 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8618 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.5796 | 1 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.5796 | 0.6705 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5796 | 0.6705 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0347 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0347 | 0.0599 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0347 | 0.0344 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.5796 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0347 | 0.5 |
Echinococcus granulosus | expressed conserved protein | 0.0175 | 0.5572 | 0.9614 |
Echinococcus multilocularis | expressed conserved protein | 0.0175 | 0.5572 | 0.9611 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0347 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0053 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0347 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.5796 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0347 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5796 | 0.6705 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8618 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0053 | 0.0091 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0053 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0347 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.122 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 3.6626 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 10 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.