TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 369.414 | Formula: C20H23N3O4
H donors: 2 H acceptors: 3 LogP: 1.76 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCN(C(=O)/C=C/c1ccc(o1)C)CC(=O)Nc1ccc(cc1)NC(=O)C
InChi: 1S/C20H23N3O4/c1-4-23(20(26)12-11-18-10-5-14(2)27-18)13-19(25)22-17-8-6-16(7-9-17)21-15(3)24/h5-12H,4,13H2,1-3H3,(H,21,24)(H,22,25)/b12-11+
InChiKey: KWTXEICESVMIRS-VAWYXSNFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	amine GPCR	0.0195	0.9386	1
Onchocerca volvulus		0.0195	0.9386	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0195	0.9386	1
Brugia malayi	hypothetical protein	0.0195	0.9386	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0195	0.9386	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0195	0.9386	0.9386
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	hypothetical protein	0.0178	0.822	0.8758
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0195	0.9386	0.9386
Echinococcus granulosus	somatostatin receptor	0.0195	0.9386	0.9386
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Brugia malayi	ORL1-like opioid receptor	0.0195	0.9386	1
Echinococcus multilocularis	g protein coupled receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	fmrfamide receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Schistosoma mansoni	opsin-like receptor	0.0195	0.9386	1
Echinococcus granulosus	neuropeptide receptor	0.0195	0.9386	0.9386
Echinococcus multilocularis	neuropeptide Y receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	neuropeptide F receptor	0.0195	0.9386	1
Echinococcus granulosus	neuropeptides capa receptor	0.0195	0.9386	0.9386
Echinococcus granulosus	sex peptide receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	growth hormone secretagogue receptor	0.0195	0.9386	1
Brugia malayi	neuropeptide F receptor	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Onchocerca volvulus		0.0195	0.9386	0.5
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Brugia malayi	Melatonin receptor type 1A	0.0195	0.9386	1
Echinococcus granulosus	G protein coupled receptor 139	0.0195	0.9386	0.9386
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	neuropeptide s receptor	0.0195	0.9386	0.9386
Brugia malayi	follicle stimulating hormone receptor	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Brugia malayi	larval opioid receptor	0.0195	0.9386	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0195	0.9386	0.9386
Echinococcus granulosus	7TM GPCR rhodopsin	0.0195	0.9386	0.9386
Schistosoma mansoni	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	somatostatin receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0195	0.9386	1
Brugia malayi	Serotonin receptor	0.0195	0.9386	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0195	0.9386	0.9386
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	neuropeptide receptor A26	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0195	0.9386	1
Brugia malayi	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0195	0.9386	0.9386
Brugia malayi	hypothetical protein	0.0195	0.9386	1
Onchocerca volvulus		0.0195	0.9386	0.5
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0195	0.9386	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0195	0.9386	0.5
Onchocerca volvulus		0.0195	0.9386	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	hypothetical protein	0.0195	0.9386	0.9386
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	TYRA-2 protein	0.0195	0.9386	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0195	0.9386	0.9386
Brugia malayi	GnHR receptor homolog	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0195	0.9386	1
Echinococcus multilocularis	fmrfamide receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	amine GPCR	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Schistosoma mansoni	adenoreceptor	0.0195	0.9386	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0195	0.9386	0.9386
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0195	0.9386	1
Schistosoma mansoni	opsin-like receptor	0.0195	0.9386	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0195	0.9386	1
Schistosoma mansoni	neuropeptide receptor	0.0195	0.9386	1
Onchocerca volvulus		0.0195	0.9386	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0195	0.9386	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0195	0.9386	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0195	0.9386	0.9386
Brugia malayi	neuropeptide F receptor	0.0195	0.9386	1
Brugia malayi	Serotonin receptor	0.0195	0.9386	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0195	0.9386	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0195	0.9386	1
Brugia malayi	Dopamine receptor	0.0195	0.9386	1
Schistosoma mansoni	biogenic amine receptor	0.0195	0.9386	1
Echinococcus multilocularis	orexin receptor type 2	0.0195	0.9386	0.9386
Schistosoma mansoni	biogenic amine receptor	0.0195	0.9386	1
Echinococcus granulosus	orexin receptor type 2	0.0195	0.9386	0.9386
Echinococcus multilocularis	g protein coupled receptor	0.0195	0.9386	0.9386
Onchocerca volvulus		0.0195	0.9386	0.5
Onchocerca volvulus		0.0195	0.9386	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0195	0.9386	0.9386
Onchocerca volvulus		0.0195	0.9386	0.5
Onchocerca volvulus		0.0195	0.9386	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0195	0.9386	1
Onchocerca volvulus		0.0195	0.9386	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0195	0.9386	0.9386
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0195	0.9386	0.9386
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0195	0.9386	0.9386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0195	0.9386	1
Schistosoma mansoni	biogenic amine receptor	0.0195	0.9386	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	g protein coupled receptor	0.0195	0.9386	0.9386
Onchocerca volvulus		0.0195	0.9386	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0195	0.9386	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0195	0.9386	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0195	0.9386	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	fmrfamide receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0195	0.9386	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0195	0.9386	1
Brugia malayi	sulfakinin receptor protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Brugia malayi	hypothetical protein	0.0195	0.9386	1
Brugia malayi	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	neuropeptides capa receptor	0.0195	0.9386	0.9386
Onchocerca volvulus		0.0195	0.9386	0.5
Echinococcus granulosus	serotonin receptor	0.0195	0.9386	0.9386
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0195	0.9386	0.9386
Brugia malayi	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0195	0.9386	0.9386
Brugia malayi	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0195	0.9386	0.9386
Schistosoma mansoni	myosin xvIII	0.0195	0.9386	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0195	0.9386	0.9386
Echinococcus granulosus	allatostatin A receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0195	0.9386	0.9386
Brugia malayi	hypothetical protein	0.0195	0.9386	1
Onchocerca volvulus		0.0195	0.9386	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0195	0.9386	1
Onchocerca volvulus		0.0195	0.9386	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0195	0.9386	1
Echinococcus multilocularis	serotonin receptor	0.0195	0.9386	0.9386
Onchocerca volvulus		0.0195	0.9386	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Echinococcus granulosus	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Echinococcus granulosus	tm gpcr rhodopsin	0.0195	0.9386	0.9386
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0195	0.9386	1
Echinococcus multilocularis	neuropeptide s receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0195	0.9386	1
Echinococcus multilocularis	sex peptide receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	amine GPCR	0.0195	0.9386	1
Echinococcus multilocularis	neuropeptide receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	neuropeptide receptor	0.0195	0.9386	1
Schistosoma mansoni	amine GPCR	0.0195	0.9386	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0195	0.9386	0.9386
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0195	0.9386	0.9386
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Schistosoma mansoni	neuropeptide F-like receptor	0.0195	0.9386	1
Brugia malayi	Dopamine receptor protein 1	0.0195	0.9386	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0195	0.9386	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0195	0.9386	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Schistosoma mansoni	opsin-like receptor	0.0195	0.9386	1
Onchocerca volvulus		0.0195	0.9386	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	kinesin family 1	0.0205	1	1
Schistosoma mansoni	hypothetical protein	0.0195	0.9386	1
Schistosoma mansoni	neuropeptide receptor	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	neuropeptide Y receptor	0.0195	0.9386	0.9386
Brugia malayi	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0195	0.9386	0.9386
Brugia malayi	putative neuropeptide receptor NPR1	0.0195	0.9386	1
Brugia malayi	RE15519p	0.0195	0.9386	1
Echinococcus multilocularis	neuropeptide receptor	0.0195	0.9386	0.9386
Echinococcus multilocularis	neuropeptides capa receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	neuropeptide receptor	0.0195	0.9386	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0195	0.9386	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0195	0.9386	0.9386
Onchocerca volvulus		0.0195	0.9386	0.5
Echinococcus granulosus	neuropeptide receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0195	0.9386	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0195	0.9386	1
Schistosoma mansoni	amine GPCR	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Brugia malayi	G-protein coupled receptor	0.0195	0.9386	1
Echinococcus granulosus	g protein coupled receptor	0.0195	0.9386	0.9386
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0195	0.9386	0.9386
Brugia malayi	G-protein coupled receptor	0.0195	0.9386	1
Brugia malayi	AKH receptor	0.0195	0.9386	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0195	0.9386	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0195	0.9386	0.9386
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0195	0.9386	0.9386
Schistosoma mansoni	histamine h1 receptor	0.0195	0.9386	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0195	0.9386	0.9386
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0195	0.9386	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0195	0.9386	0.9386
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0195	0.9386	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0195	0.9386	0.9386
Brugia malayi	G protein-coupled receptor	0.0195	0.9386	1
Echinococcus multilocularis	allatostatin A receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0195	0.9386	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	G-protein coupled receptor	0.0195	0.9386	1
Echinococcus multilocularis	g-protein coupled receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0195	0.9386	0.9386
Brugia malayi	G protein-coupled receptor F59B2.13	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	g protein coupled receptor	0.0195	0.9386	0.9386
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0195	0.9386	0.9386
Brugia malayi	hypothetical protein	0.0195	0.9386	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0195	0.9386	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0195	0.9386	1
Brugia malayi	Dopamine receptor protein 2	0.0195	0.9386	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0195	0.9386	0.9386
Schistosoma mansoni	neuropeptide f receptor 76f	0.0195	0.9386	1
Echinococcus granulosus	g protein coupled receptor	0.0195	0.9386	0.9386
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0195	0.9386	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.9386	1
Echinococcus multilocularis	serotonin receptor	0.0195	0.9386	0.9386
Echinococcus multilocularis	G protein coupled receptor 139	0.0195	0.9386	0.9386
Brugia malayi	putative neuropeptide receptor	0.0195	0.9386	1
Schistosoma mansoni	hypothetical protein	0.0195	0.9386	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 44.6684 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference
Potency (functional)	125.8925 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1551363

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1410367