Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Ras converting CAAX endopeptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Saccharomyces cerevisiae | Rce1p | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | Ras converting CAAX endopeptidase 1 | 225 aa | 181 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 1 | 1 |
Mycobacterium tuberculosis | Probable integral membrane protein | 0.0046 | 0 | 0.5 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0046 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0221 | 1 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0221 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0221 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0046 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0046 | 0 | 0.5 |
Plasmodium vivax | protease, putative | 0.0046 | 0 | 0.5 |
Plasmodium falciparum | protease, putative | 0.0046 | 0 | 0.5 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0221 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0046 | 0 | 0.5 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0221 | 1 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0046 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0221 | 1 | 0.5 |
Chlamydia trachomatis | hypothetical protein | 0.0046 | 0 | 0.5 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0221 | 1 | 1 |
Mycobacterium ulcerans | integral membrane protein | 0.0046 | 0 | 0.5 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0221 | 1 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0221 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0046 | 0 | 0.5 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0221 | 1 | 0.5 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0221 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 0.5504 uM | PUBCHEM_BIOASSAY: Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
AC50 (binding) | = 4.85 uM | PUBCHEM_BIOASSAY: Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
AC50 (binding) | = 17.3 uM | PUBCHEM_BIOASSAY: Human Ras-Converting Enzyme Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-04_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
AC50 (binding) | = 60.58 uM | PUBCHEM_BIOASSAY: Human Ras-Converting Enzyme Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-04_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.