Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0035 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0035 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.5 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.5 | 0.5 | |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0035 | 0.5 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0035 | 0.5 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0035 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.5 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0035 | 0.5 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0035 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.