Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | DNA-directed RNA polymerase II RPB1 | 0.00638249 | 0.278233 | 0.234905 |
Chlamydia trachomatis | DNA-directed RNA polymerase subunit beta' | 0.00638249 | 0.278233 | 0.5 |
Echinococcus multilocularis | DNA directed RNA polymerase III subunit RPC1 | 0.00638249 | 0.278233 | 0.302918 |
Echinococcus multilocularis | DNA directed RNA polymerase I subunit RPA1 | 0.0177427 | 0.918507 | 1 |
Echinococcus multilocularis | DNA directed RNA polymerase II subunit | 0.00638249 | 0.278233 | 0.302918 |
Trypanosoma brucei | DNA-directed RNA polymerase II subunit RPB1 | 0.00638249 | 0.278233 | 0.257116 |
Trypanosoma cruzi | DNA-directed rna polymerase I largest subunit, putative | 0.0177427 | 0.918507 | 1 |
Trichomonas vaginalis | DNA-directed RNA polymerase I largest subunit, putative | 0.00638249 | 0.278233 | 0.302918 |
Schistosoma mansoni | DNA-directed RNA polymerase II largest subunit | 0.00638249 | 0.278233 | 0.22879 |
Loa Loa (eye worm) | hypothetical protein | 0.0191886 | 1 | 1 |
Trypanosoma brucei | RNA polymerase IIA largest subunit | 0.00638249 | 0.278233 | 0.257116 |
Trypanosoma brucei | DNA-directed RNA polymerase III largest subunit, putative | 0.00393181 | 0.140109 | 0.0968564 |
Plasmodium falciparum | DNA-directed RNA polymerase III subunit RPC1, putative | 0.00638249 | 0.278233 | 0.22879 |
Trypanosoma brucei | DNA-directed RNA polymerase I largest subunit | 0.0177427 | 0.918507 | 1 |
Entamoeba histolytica | DNA-directed RNA polymerase I largest subunit, putative | 0.0191886 | 1 | 1 |
Plasmodium falciparum | RNA polymerase I | 0.0191886 | 1 | 1 |
Brugia malayi | RNA polymerase Rpb1, domain 2 family protein | 0.0191886 | 1 | 1 |
Plasmodium vivax | DNA-directed RNA polymerase I 190 kDa polypeptide, putative | 0.0191886 | 1 | 1 |
Mycobacterium ulcerans | DNA-directed RNA polymerase subunit beta' | 0.00638249 | 0.278233 | 0.5 |
Mycobacterium leprae | DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT). | 0.00638249 | 0.278233 | 0.5 |
Leishmania major | DNA-directed rna polymerase I largest subunit, putative | 0.0177427 | 0.918507 | 1 |
Echinococcus granulosus | DNA directed RNA polymerase I subunit RPA1 | 0.0177427 | 0.918507 | 1 |
Trypanosoma brucei | DNA-directed rna polymerase I largest subunit, putative | 0.0177427 | 0.918507 | 1 |
Plasmodium falciparum | DNA-directed RNA polymerase II subunit RPB1 | 0.00638249 | 0.278233 | 0.22879 |
Trichomonas vaginalis | RNA polymerase A, putative | 0.0177427 | 0.918507 | 1 |
Trichomonas vaginalis | DNA-directed RNA polymerase I largest subunit, putative | 0.00638249 | 0.278233 | 0.302918 |
Toxoplasma gondii | DNA-directed RNA polymerase I RPA1 | 0.0191886 | 1 | 1 |
Trypanosoma brucei | DNA-directed RNA polymerase III subunit C1 | 0.00638249 | 0.278233 | 0.257116 |
Trichomonas vaginalis | DNA-directed RNA polymerase, putative | 0.00258339 | 0.0641103 | 0.0697984 |
Giardia lamblia | RNA polymerase AI large subunit | 0.0191886 | 1 | 1 |
Schistosoma mansoni | RNA polymerase Rpb1 | 0.00638249 | 0.278233 | 0.22879 |
Treponema pallidum | DNA-directed RNA polymerase subunit beta' | 0.00638249 | 0.278233 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA-directed RNA polymerase subunit beta/beta' | 0.00638249 | 0.278233 | 0.5 |
Schistosoma mansoni | DNA-directed RNA polymerase I | 0.0191886 | 1 | 1 |
Toxoplasma gondii | DNA-directed RNA polymerase III RPC1 | 0.00638249 | 0.278233 | 0.234905 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8.6 ng ml-1 | In vitro antimalarial activity against Plasmodium falciparum W-2 (Indochina clone) | ChEMBL. | 8355254 |
IC50 (functional) | = 8.6 ng ml-1 | In vitro antimalarial activity against Plasmodium falciparum W-2 (Indochina clone) | ChEMBL. | 8355254 |
IC50 (functional) | = 10 ng ml-1 | In vitro antimalarial activity against Plasmodium falciparum D-6 (Sierra Leone clone) | ChEMBL. | 8355254 |
IC50 (functional) | = 10 ng ml-1 | In vitro antimalarial activity against Plasmodium falciparum D-6 (Sierra Leone clone) | ChEMBL. | 8355254 |
IC50 (functional) | = 5.2 nM ml-1 | In vitro antimalarial activity against Plasmodium falciparum D-6 (Sierra Leone clone) relative to the activity of artemisinin | ChEMBL. | 8355254 |
IC50 (functional) | = 5.2 nM ml-1 | In vitro antimalarial activity against Plasmodium falciparum D-6 (Sierra Leone clone) relative to the activity of artemisinin | ChEMBL. | 8355254 |
IC50 (functional) | = 8.6 nM ml-1 | In vitro antimalarial activity against Plasmodium falciparum W-2 (Indochina clone) relative to the activity of artemisinin | ChEMBL. | 8355254 |
IC50 (functional) | = 8.6 nM ml-1 | In vitro antimalarial activity against Plasmodium falciparum W-2 (Indochina clone) relative to the activity of artemisinin | ChEMBL. | 8355254 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 8355254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.