Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor | 0.1166 | 0.3042 | 0.3335 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.2005 | 0.6319 | 0.6319 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0613 | 0.088 | 0.088 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0388 | 0 | 0.5 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0613 | 0.088 | 0.1122 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.2393 | 0.7838 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.1166 | 0.3042 | 0.3881 |
Loa Loa (eye worm) | hypothetical protein | 0.2946 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0941 | 0.2162 | 0.2162 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.2168 | 0.6958 | 0.8878 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.2721 | 0.912 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.2946 | 1 | 1 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0613 | 0.088 | 0.088 |
Loa Loa (eye worm) | glutamate receptor | 0.2393 | 0.7838 | 0.7838 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.2005 | 0.6319 | 0.6929 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.2005 | 0.6319 | 0.6319 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0388 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 0.088 | 0.088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 19.2 ug ml-1 | In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | ChEMBL. | 12852973 |
IC50 (binding) | = 19.2 ug ml-1 | In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | ChEMBL. | 12852973 |
IC50 (binding) | = 21 ug ml-1 | In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramate dehydrogenase | ChEMBL. | 12852973 |
IC50 (binding) | = 21 ug ml-1 | In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramate dehydrogenase | ChEMBL. | 12852973 |
IC50 (binding) | > 25 ug ml-1 | In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramoyl-L-alanine synthetase | ChEMBL. | 12852973 |
IC50 (binding) | > 25 ug ml-1 | In vitro inhibitory activity against Staphylococcus aureus UDP-N-acetylmuramoyl-L-alanine synthetase | ChEMBL. | 12852973 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory activity against Staphylococcus pneumoniae GC1894 (PRSP) | ChEMBL. | 12852973 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory activity against Staphylococcus aureus GC 4543 (MSSA) | ChEMBL. | 12852973 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory activity against Staphylococcus aureus GC 2216 (ATCC) | ChEMBL. | 12852973 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory activity against MSCNS GC 646 | ChEMBL. | 12852973 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory activity against Staphylococcus aureus GC 1131 (MRSA) | ChEMBL. | 12852973 |
MIC (functional) | = 8 ug ml-1 | Minimum inhibitory activity against Enterococcus faecalis GC 2242 (VRE) | ChEMBL. | 12852973 |
MIC (functional) | = 16 ug ml-1 | Minimum inhibitory activity against Enterococcus faecalis GC 4555 (ATCC) | ChEMBL. | 12852973 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory activity in presence of 4% bovine serum albumin against Staphylococcus pneumoniae GC1894 (PRSP) | ChEMBL. | 12852973 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory activity against Escherichia coli GC 4559 | ChEMBL. | 12852973 |
MIC (functional) | = 128 ug ml-1 | Minimum inhibitory activity against Escherichia coli GC 4560 | ChEMBL. | 12852973 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory activity against Escherichia coli GC 4559 | ChEMBL. | 12852973 |
MIC (functional) | = 128 ug ml-1 | Minimum inhibitory activity against Escherichia coli GC 4560 | ChEMBL. | 12852973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.