Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.312 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0096 | 0.1002 | 0.3213 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0087 | 0.0864 | 0.547 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0093 | 0.0093 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0096 | 0.1004 | 0.1004 |
Entamoeba histolytica | hypothetical protein | 0.0185 | 0.2334 | 1 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0237 | 0.312 | 0.312 |
Onchocerca volvulus | 0.0237 | 0.312 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2123 | 0.2123 |
Brugia malayi | endochitinase | 0.015 | 0.1802 | 0.5776 |
Mycobacterium tuberculosis | Possible chitinase | 0.0128 | 0.1472 | 1 |
Echinococcus granulosus | geminin | 0.0171 | 0.2123 | 0.2123 |
Onchocerca volvulus | Putative endochitinase | 0.0168 | 0.2073 | 0.6643 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0096 | 0.1002 | 0.1002 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0097 | 0.101 | 0.6557 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0185 | 0.2334 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0038 | 0.0131 | 0.0421 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0096 | 0.1004 | 0.1004 |
Entamoeba histolytica | protein kinase, putative | 0.0185 | 0.2334 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0038 | 0.0131 | 0.0421 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0093 | 0.0093 |
Onchocerca volvulus | Putative endochitinase | 0.0168 | 0.2073 | 0.6643 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0237 | 0.312 | 0.312 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.2315 | 0.742 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | chitinase I | 0.015 | 0.1802 | 0.5776 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0087 | 0.0864 | 0.547 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.2315 | 0.742 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0173 | 0.0173 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 0.2334 | 0.2334 |
Onchocerca volvulus | Putative endochitinase | 0.015 | 0.1802 | 0.5776 |
Plasmodium vivax | glutathione reductase, putative | 0.0038 | 0.0131 | 0.0421 |
Brugia malayi | Endochitinase | 0.0168 | 0.2073 | 0.6643 |
Onchocerca volvulus | Putative endochitinase | 0.0168 | 0.2073 | 0.6643 |
Schistosoma mansoni | jumonji domain containing protein | 0.0077 | 0.0707 | 0.0707 |
Brugia malayi | Protein kinase domain containing protein | 0.0185 | 0.2334 | 0.748 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0038 | 0.0131 | 0.0421 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.1002 | 0.3955 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0185 | 0.2334 | 0.748 |
Brugia malayi | glutathione reductase | 0.0038 | 0.0131 | 0.0421 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0237 | 0.312 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0237 | 0.312 | 1 |
Giardia lamblia | Kinase, PLK | 0.0096 | 0.1002 | 1 |
Onchocerca volvulus | 0.0237 | 0.312 | 1 | |
Plasmodium falciparum | conserved protein, unknown function | 0.0237 | 0.312 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0185 | 0.2334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1472 | 0.4717 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0096 | 0.1002 | 0.3213 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0093 | 0.0297 |
Schistosoma mansoni | kinase | 0.0049 | 0.03 | 0.03 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0087 | 0.0864 | 0.547 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0146 | 0.1742 | 0.5584 |
Entamoeba histolytica | chitinase, putative | 0.015 | 0.1802 | 0.6005 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.1002 | 0.1002 |
Echinococcus multilocularis | dual specificity | 0.0185 | 0.2334 | 0.2334 |
Loa Loa (eye worm) | cuticular endochitinase | 0.015 | 0.1802 | 0.5776 |
Entamoeba histolytica | protein kinase, putative | 0.0185 | 0.2334 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0093 | 0.0297 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0038 | 0.0131 | 0.0421 |
Onchocerca volvulus | Putative endochitinase | 0.015 | 0.1802 | 0.5776 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0128 | 0.1472 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0038 | 0.0131 | 0.0421 |
Toxoplasma gondii | hypothetical protein | 0.0237 | 0.312 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0185 | 0.2334 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0039 | 0.0139 | 0.0139 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0087 | 0.0864 | 0.547 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0315 | 0.101 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0185 | 0.2334 | 1 |
Echinococcus multilocularis | geminin | 0.0171 | 0.2123 | 0.2123 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2123 | 0.2123 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0039 | 0.0139 | 0.0139 |
Leishmania major | chitinase | 0.015 | 0.1802 | 0.7585 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.047 | 0.1505 |
Schistosoma mansoni | hypothetical protein | 0.0237 | 0.312 | 0.312 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0096 | 0.1002 | 0.3213 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0096 | 0.1002 | 0.3955 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0185 | 0.2334 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0093 | 0.0093 |
Mycobacterium tuberculosis | Probable reductase | 0.0087 | 0.0864 | 0.547 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.1002 | 0.3955 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.312 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0097 | 0.101 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0038 | 0.0131 | 0.0421 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0097 | 0.101 | 0.6557 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0696 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0038 | 0.0131 | 0.0421 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0096 | 0.1002 | 0.3955 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0128 | 0.1472 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0185 | 0.2334 | 0.2334 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0696 | 1 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0087 | 0.0864 | 0.547 |
Brugia malayi | jmjC domain containing protein | 0.0096 | 0.1004 | 0.3217 |
Brugia malayi | endochitinase | 0.0168 | 0.2073 | 0.6643 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0096 | 0.1002 | 0.1002 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0097 | 0.101 | 0.6557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.