Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0185 | 0.2334 | 1 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0237 | 0.312 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0696 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.047 | 0.1505 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0097 | 0.101 | 0.6557 |
Mycobacterium tuberculosis | Possible chitinase | 0.0128 | 0.1472 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0093 | 0.0093 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.312 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Brugia malayi | endochitinase | 0.0168 | 0.2073 | 0.6643 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0696 | 1 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0087 | 0.0864 | 0.547 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1472 | 0.4717 |
Mycobacterium tuberculosis | Probable reductase | 0.0087 | 0.0864 | 0.547 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Plasmodium falciparum | conserved protein, unknown function | 0.0237 | 0.312 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0168 | 0.2073 | 0.6643 |
Schistosoma mansoni | hypothetical protein | 0.0237 | 0.312 | 0.312 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0097 | 0.101 | 0.6557 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0087 | 0.0864 | 0.547 |
Entamoeba histolytica | protein kinase, putative | 0.0185 | 0.2334 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0096 | 0.1002 | 0.3213 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0173 | 0.0173 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0097 | 0.101 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0038 | 0.0131 | 0.0421 |
Brugia malayi | Endochitinase | 0.0168 | 0.2073 | 0.6643 |
Echinococcus multilocularis | dual specificity | 0.0185 | 0.2334 | 0.2334 |
Loa Loa (eye worm) | cuticular endochitinase | 0.015 | 0.1802 | 0.5776 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0315 | 0.101 |
Schistosoma mansoni | kinase | 0.0049 | 0.03 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.312 | 1 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0128 | 0.1472 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0093 | 0.0297 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0185 | 0.2334 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0096 | 0.1004 | 0.1004 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0185 | 0.2334 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0185 | 0.2334 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0096 | 0.1002 | 0.3213 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.1002 | 0.3955 |
Brugia malayi | Protein kinase domain containing protein | 0.0185 | 0.2334 | 0.748 |
Entamoeba histolytica | hypothetical protein | 0.0185 | 0.2334 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0093 | 0.0297 |
Brugia malayi | endochitinase | 0.015 | 0.1802 | 0.5776 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.2315 | 0.742 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0096 | 0.1002 | 0.1002 |
Schistosoma mansoni | jumonji domain containing protein | 0.0077 | 0.0707 | 0.0707 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0093 | 0.0093 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0039 | 0.0139 | 0.0139 |
Toxoplasma gondii | hypothetical protein | 0.0237 | 0.312 | 1 |
Leishmania major | chitinase | 0.015 | 0.1802 | 0.7585 |
Plasmodium vivax | glutathione reductase, putative | 0.0038 | 0.0131 | 0.0421 |
Echinococcus granulosus | dual specificity | 0.0185 | 0.2334 | 0.2334 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0237 | 0.312 | 0.312 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0087 | 0.0864 | 0.547 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2123 | 0.2123 |
Toxoplasma gondii | thioredoxin reductase | 0.0038 | 0.0131 | 0.0421 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0087 | 0.0864 | 0.547 |
Onchocerca volvulus | 0.0237 | 0.312 | 1 | |
Loa Loa (eye worm) | glutathione reductase | 0.0038 | 0.0131 | 0.0421 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0096 | 0.1002 | 0.1002 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0096 | 0.1004 | 0.1004 |
Onchocerca volvulus | 0.0237 | 0.312 | 1 | |
Onchocerca volvulus | Putative endochitinase | 0.0168 | 0.2073 | 0.6643 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0096 | 0.1002 | 0.3955 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 0.2334 | 0.2334 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Loa Loa (eye worm) | chitinase I | 0.015 | 0.1802 | 0.5776 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.2315 | 0.742 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.1002 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0168 | 0.2073 | 0.6643 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0128 | 0.1472 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0185 | 0.2334 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.015 | 0.1802 | 0.5776 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0096 | 0.1002 | 0.3213 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0237 | 0.312 | 0.312 |
Echinococcus granulosus | geminin | 0.0171 | 0.2123 | 0.2123 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0087 | 0.0864 | 0.547 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0093 | 0.0093 |
Trypanosoma brucei | polo-like protein kinase | 0.0096 | 0.1002 | 0.3955 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.1002 | 0.1002 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2123 | 0.2123 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0146 | 0.1742 | 0.5584 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0173 | 0.0173 |
Brugia malayi | jmjC domain containing protein | 0.0096 | 0.1004 | 0.3217 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0185 | 0.2334 | 0.748 |
Plasmodium vivax | hypothetical protein, conserved | 0.0237 | 0.312 | 1 |
Brugia malayi | glutathione reductase | 0.0038 | 0.0131 | 0.0421 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0097 | 0.101 | 0.6557 |
Plasmodium falciparum | glutathione reductase | 0.0038 | 0.0131 | 0.0421 |
Plasmodium falciparum | thioredoxin reductase | 0.0038 | 0.0131 | 0.0421 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0039 | 0.0139 | 0.0139 |
Onchocerca volvulus | Putative endochitinase | 0.015 | 0.1802 | 0.5776 |
Entamoeba histolytica | protein kinase, putative | 0.0185 | 0.2334 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.1002 | 0.3955 |
Echinococcus multilocularis | geminin | 0.0171 | 0.2123 | 0.2123 |
Brugia malayi | Thioredoxin reductase | 0.0038 | 0.0131 | 0.0421 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0038 | 0.0131 | 0.0421 |
Giardia lamblia | Kinase, PLK | 0.0096 | 0.1002 | 1 |
Entamoeba histolytica | chitinase, putative | 0.015 | 0.1802 | 0.6005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.