Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0207 | 0.6992 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0207 | 0.6992 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.6992 | 1 |
Brugia malayi | hypothetical protein | 0.0207 | 0.6992 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.5975 | 0.8546 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0132 | 0.3758 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0207 | 0.6992 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0093 | 0.2112 | 0.5622 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0052 | 0.0377 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0132 | 0.3758 | 0.5375 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0052 | 0.0377 | 0.0377 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0207 | 0.6992 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0052 | 0.0377 | 0.0377 |
Echinococcus granulosus | prolyl endopeptidase | 0.0132 | 0.3758 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0183 | 0.5975 | 0.8546 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0132 | 0.3758 | 0.6289 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Leishmania major | oligopeptidase b | 0.0052 | 0.0377 | 0.0539 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0207 | 0.6992 | 0.5 |
Trypanosoma cruzi | oligopeptidase b | 0.0052 | 0.0377 | 0.0539 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0093 | 0.2112 | 0.5622 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0132 | 0.3758 | 0.5375 |
Trypanosoma brucei | oligopeptidase b | 0.0052 | 0.0377 | 0.0539 |
Trypanosoma brucei | prolyl endopeptidase | 0.0132 | 0.3758 | 0.5375 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0207 | 0.6992 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0052 | 0.0377 | 0.0539 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0052 | 0.0377 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.3758 | 0.5375 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0052 | 0.0377 | 0.0539 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0132 | 0.3758 | 1 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0052 | 0.0377 | 0.0539 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0207 | 0.6992 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.2112 | 0.5622 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0132 | 0.3758 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0132 | 0.3758 | 0.5375 |
Leishmania major | hypothetical protein, conserved | 0.0207 | 0.6992 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0132 | 0.3758 | 0.5375 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0052 | 0.0377 | 1 |
Brugia malayi | hypothetical protein | 0.0134 | 0.3856 | 0.5515 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0118 | 0.3169 | 0.3169 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0183 | 0.5975 | 1 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0052 | 0.0377 | 0.0539 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0052 | 0.0377 | 0.0539 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.