Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E receptor 1 (subtype EP1), 42kDa | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 3 (subtype EP3) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 2 (subtype EP2), 53kDa | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 4 (subtype EP4) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0184 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.018 | 0.8848 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.018 | 0.8848 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 1 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.018 | 0.8848 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0184 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0184 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0184 | 1 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0184 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0184 | 1 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0184 | 1 | 1 |
Onchocerca volvulus | 0.0184 | 1 | 0.5 | |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0184 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0184 | 1 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0184 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.018 | 0.8848 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.018 | 0.8848 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.018 | 0.8848 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.083 uM | Binding affinity at human Prostanoid EP1 receptor. | ChEMBL. | 12182865 |
Ki (binding) | = 0.083 uM | Binding affinity at human Prostanoid EP1 receptor. | ChEMBL. | 12182865 |
Ki (binding) | = 0.51 uM | Binding affinity at human Prostanoid EP3 receptor. | ChEMBL. | 12182865 |
Ki (binding) | = 0.51 uM | Binding affinity at human Prostanoid EP3 receptor. | ChEMBL. | 12182865 |
Ki (binding) | = 1.5 uM | Binding affinity at human Prostanoid EP4 receptor. | ChEMBL. | 12182865 |
Ki (binding) | = 1.5 uM | Binding affinity at human Prostanoid EP4 receptor. | ChEMBL. | 12182865 |
Ki (binding) | = 3.8 uM | Binding affinity at human Prostanoid EP2 receptor. | ChEMBL. | 12182865 |
Ki (binding) | = 3.8 uM | Binding affinity at human Prostanoid EP2 receptor. | ChEMBL. | 12182865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.