Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | complement component 5a receptor 1 | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | G-protein coupled receptor, putative | complement component 5a receptor 1 | 350 aa | 293 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.2795 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0781 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.4363 | 0.444 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1914 | 0.1948 |
Echinococcus granulosus | potassium voltage gated channel subfamily KQT | 0.0277 | 0.4363 | 0.4363 |
Schistosoma mansoni | dihydrofolate reductase | 0.0053 | 0.0634 | 0.0634 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0053 | 0.0634 | 0.0634 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1914 | 0.1914 |
Echinococcus granulosus | dihydrofolate reductase | 0.0053 | 0.0634 | 0.0634 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0277 | 0.4363 | 0.4363 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1914 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0053 | 0.0634 | 0.0645 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.1914 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1914 | 0.1914 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2795 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2795 | 0.5 |
Onchocerca volvulus | 0.013 | 0.1914 | 1 | |
Brugia malayi | Dihydrofolate reductase | 0.0053 | 0.0634 | 0.0634 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2795 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0053 | 0.0634 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.4363 | 0.444 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.0781 | 0.1148 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0045 | 0.0494 | 0.0503 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0615 | 1 | 1 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0615 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.1914 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0781 | 0.0781 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0277 | 0.4363 | 0.444 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2795 | 0.5 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0605 | 0.9827 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1914 | 0.1914 |
Brugia malayi | dihydrofolate reductase family protein | 0.0053 | 0.0634 | 0.0634 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0615 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2795 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1914 | 0.1914 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0 ug ml-1 | Compound was tested for the induction of nonspecific myeloperoxidase(MPO) release | ChEMBL. | 1310118 |
EC50 (functional) | = 0 ug ml-1 | Compound was tested for the induction of nonspecific myeloperoxidase(MPO) release | ChEMBL. | 1310118 |
EC50 (functional) | = 4 ug ml-1 | Compound was tested for the inhibition of C5a- induced human neutrophil activation | ChEMBL. | 1310118 |
EC50 (functional) | = 4 ug ml-1 | Compound was tested for the inhibition of fMLF- induced human neutrophil activation | ChEMBL. | 1310118 |
EC50 (functional) | = 4 ug ml-1 | Compound was tested for the inhibition of C5a- induced human neutrophil activation | ChEMBL. | 1310118 |
EC50 (functional) | = 4 ug ml-1 | Compound was tested for the inhibition of fMLF- induced human neutrophil activation | ChEMBL. | 1310118 |
IC50 (binding) | = 9 ug ml-1 | Ability to inhibit binding of radiolabeled C5a anaphylatoxin to intact membrane bound receptor from human neutrophils. | ChEMBL. | 1310118 |
IC50 (binding) | = 9 ug ml-1 | Ability to inhibit binding of radiolabeled C5a anaphylatoxin to intact membrane bound receptor from human neutrophils. | ChEMBL. | 1310118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.