Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0306 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0306 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0306 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0306 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0306 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0306 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0306 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0306 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0306 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0306 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.