Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | galactosylceramidase | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0625 | 0.619 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0625 | 0.619 | 0.5 |
Echinococcus multilocularis | Transglutaminase | 0.0625 | 0.619 | 0.619 |
Mycobacterium tuberculosis | Conserved protein | 0.0625 | 0.619 | 0.5 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0625 | 0.619 | 0.5 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0625 | 0.619 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0625 | 0.619 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Onchocerca volvulus | 0.0801 | 0.9413 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0625 | 0.619 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Mycobacterium tuberculosis | Long conserved protein | 0.0625 | 0.619 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0625 | 0.619 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0625 | 0.619 | 0.5 |
Brugia malayi | Thioredoxin family protein | 0.0625 | 0.619 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0625 | 0.619 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0625 | 0.619 | 0.5 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0625 | 0.619 | 0.5 |
Echinococcus granulosus | Transglutaminase | 0.0625 | 0.619 | 0.619 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0625 | 0.619 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.